报告题目： Wireless blood pressure monitoring system for animal and human
报告人：王青 研究员
时间：2014年9月29号上午10:00
地点：南一楼中311室
报告人单位: Centre Hospitalier Universitaire Vaudois/University Hospital of Lausanne
报告人简介:
Qing Wang, M.D., researcher project leader, Division of Nephrology and Hypertension, University Hospital/ CHUV, University of Lausanne, Switzerland; Guest research fellow, Chinese Hypertension League Institute in Beijing, and adjunct professor, Huazhong University of Science & Technology in Wuhan, China; Members of American Physiological Society, European Society of Cardiology, and World Action on Salt and Health (WASH); Overseas representative for the Annual Sessions of the 11th National Committee of the Chinese People's Political Consultative Conference (CPPCC) and member of the board of directors of Beijing Chinese Overseas Friendship Association.
报告摘要:
Today, hypertension affects approximately 25% of the adult population worldwide, and its prevalence is predicted to increase by 60% by 2025, when a total of 1.56 billion people may be affected. Hypertension is the most important risk factor leading to cardiovascular diseases (CVD) and causing 62% stroke and 49% myocardial infarction (or coronary heart disease). According to WHO report in 2011, among a total global death of 55 million, 17 million or 30% of death was due to CVD and will rise to 23.4 million in 2030. Small rodent such as mouse and rat are widely used for investigating the pathogenesis of Human hypertension, cardiovascular diseases, diabetes, etc and for developing new diagnosis and therapeutic strategies. Wireless biosensors are increasingly being used for improving vital signal monitory system, solving a wide variety of medical and research challenges, and improving research and medical quality. This requires innovative high-precision micro technology. We have designed and generated an implantable telemetric pressure device for long-term accurately monitoring of blood pressure (BP) and heart rate in a free moving small rodent animal (mouse and rat). The telemetric device consists of a pressure sensor, a telemetry chip, and an implantable catheter. The prototypes have been proved in mice and rats. It can be adapted for continuously monitoring venous and arterial blood pressure in Human. The telemetric pressure device enables for (1) long-term accurately monitoring of arterial and venous blood pressure, right ventricular pressure, and heart rate etc, (2) drug delivery and blood sampling. Further step are (1) to generate the device with an appropriate data transmission bandwidth and couple distance for accurate monitoring of high frequency vital signals such as mouse left ventricular pressure etc and (2) for developing multi-sensing monitoring vital signals (BP, ECG, glucose, etc) in animals and patients with hypertension, cardiovascular diseases, diabetes, and others.
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