学术报告第201405期

讲座时间：3月30号（周日）下午4  点

地点：南一楼中311会议室

主讲人：Luonan Chen, Key Laboratory of Systems  Biology, Chinese  Academy of  Sciences

讲座主题:Detecting early-warning signals for complex  diseases by dynamical network biomarkers.

 Abstract:  Considerable evidence suggests that during the progression of complex diseases,  the deteriorations are not necessarily smooth but are abrupt, and may cause a  critical transition from one state to another at a tipping point. Here, we  develop a model-free method to detect early-warning signals of such critical  transitions, even with only a small number of samples. Specifically, we  theoretically derive an index based on a dynamical network biomarker (DNB) that  serves as a general early-warning signal indicating an imminent bifurcation or  sudden deterioration before the critical transition occurs. Based on theoretical  analyses, we show that predicting a sudden transition from small samples is  achievable provided that there are a large number of measurements for each  sample, e.g., high-throughput data. We employ microarray data of three diseases  to demonstrate the effectiveness of our method. The relevance of DNBs with the  diseases was also validated by related experimental data and functional  analysis.

Brief CV: Luonan Chen received BS degree in the  Electrical Engineering, from Huazhong University of Science and Technology, and  the M.E. and Ph.D. degrees in the electrical engineering, from Tohoku University, Sendai, Japan , in 1988 and 1991,  respectively. From 1997, he was an associate professor of the Osaka Sangyo  University, Osaka, Japan , and then a full Professor.  Since 2010, he has been a professor and executive director at Key Laboratory of  Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. He was the founding  director of Institute of Systems Biology, Shanghai University, and from 2010 he has also been a research  professor in Institute of  Industrial Science, University of Tokyo, Japan . He was  elected as the founding president of Computational Systems Biology Society of OR  China, and Chair of Technical Committee of Systems Biology at IEEE SMC Society.  He serves as editor or editorial board member for major systems biology related  journals, e.g. BMC Systems Biology, IEEE/ACM Trans. On Computational Biology and  Bioinformatics, Journal of Molecular Cell Biology, Mathematical Biosciences, and  Journal of the Royal Society Interface. His fields of interest are systems  biology, computational biology, and nonlinear dynamics. In recent years, he  published over 200 SCI journal papers and two monographs (books) in the area of  systems biology.